我们拥有长年累月所积累下来的合成技术,可以随需求满足从工艺开发到GMP委托生产。
GMP少量生产设备的完备,结合上我们已经拥有的GMP大型设备及多功能性设备,
使得我们能够灵活应对从数百克到大批次的生产。
基于ICH-GMP的标准,通过DMF和CEP的注册,FDA审查等经验,使得我们拥有了过硬的品控管理体制,
可以提供让客户满意的委托生产服务。
另外,我们在EHS投资方面也是不遗余力。
Facilities | Specification | Capacity | Quantity |
---|---|---|---|
Reactors Normal Pressure, -5~140℃(200℃) |
Glass Lining | 10L | 5 |
Glass Lining | 300L | 5 | |
1,000L | 1 | ||
Stainless | 300L | 3 | |
500L | 1 | ||
Autoclave ~10kg/cm2, -5~140℃ |
Stainless | 200L | 1 |
Vacuum Distilling Apparatus 3mmHg, ~200℃ |
Stainless | 200L | 1 |
Centrifuge | Top emission type, Stainless | φ12 inches | 1 |
φ20 inches | 2 | ||
φ30 inches | 1 | ||
Filter Separators | Pressurization, Stainless | 2 | |
Reduced pressure, Stainless | 2 | ||
Dryers | Shelf- fan dryer, Stainless-steel | 1 | |
Shelf-type vacuum dryer, Stainless | 1 | ||
Conical type vacuum dryer, Stainless | 30L | 1 | |
Clean Room | Clean level: 100,000/ft3 Ventilation: 20 times/hr or more |
1 | |
Freezer Medium -20℃ |
3600kcal/hr | 1 |
Facilities | Specification | Capacity | Quantity |
---|---|---|---|
Reactors Normal Pressure~100mmHg, -5~140℃(200℃) |
Glass Lining | 2m3~10m3 | 41 |
Stainless | 1m3~10m3 | 67 | |
Ti clad | 2.5m3 | 2 | |
Autoclaves ~10kg/cm2, -5~140℃ |
Stainless | 2m3~4m3 | 5 |
Glass Lining | 4m3 | 1 | |
Photo-reactor 600〜700nm |
Stainless Sodium Lamp |
1 | |
Vacuum Distilling Apparatus 3mmHg, ~180℃, N=12 |
Stainless | 1m3~7m3 | 3 |
Centrifuges | Bottom emission type, Stainless | φ24~55 inches | 5 |
Top emission type, Stainless | φ24~55 inches | 21 | |
Filter separators | Pressurization, Stainless | 18 | |
Reduced pressure, Stainless | 29 | ||
Reduced pressure, FRP | 1 | ||
Dryers | Shelf-type fan dryer, Stainless | 22 | |
Conical type vacuum dryer, Stainless | 2~2.5m3 | 6 | |
Clinical type vacuum dryer, Glass Lining | 2m3 | 2 | |
Nauta-type vacuum dryer, Stainless | 1m3 | 3 | |
2m3 | 5 | ||
Mills | Pin mill, Stainless | 9 | |
Hammer mill, Stainless | 3 | ||
Power mill, Stainless | 1 | ||
Feather mill, Stainless | 1 | ||
Jet mill, Stainless | 1 | ||
Clean Rooms | Clean level: 100,000/ft3 Ventilation: More than 20 times/hr |
Centrifuge rooms | 10 |
Drying rooms | 11 | ||
Milling rooms | 12 | ||
Ice Maker | Stainless 2.4t/day | 1 | |
Wastewater treatment | Activated sludge | ||
Freezers | Medium -20℃ Inside -10 ~ -5℃ |
46kW | 16 |
Equipment | Specification |
---|---|
HPLC | High and low pressure gradients Detector: UV, UV-VIS, RI |
GC | Detector: FID Equipped with a head-space sample injection device |
ICP-MS | Responding to elements subject to ICH-Q3D Step 4 Responding to organic solvents |
FT-IR | 7800~350cm-1 |
UV-visible spectrophotometers | 190~900nm |
Karl Fischer moisture meter | Volumetric procedure Coulometric titration |
Potentiometric titrator | pH 0.00~14.00 |
Polarimeter | 589nm (Na) |
Particle size distribution analyzer | Laser diffraction type(dry and wet), microscope type, air permeability method |
Acylation | Acid chloride, acid anhydride, etc. |
---|---|
Amidation | Ammonia, amines, etc. |
Amination | By reduction of nitro and nitroso, and by using amines |
Alkylation | Dialkyl sulfuric acid, alkyl halide, etc. |
Esterification | Various organic and inorganic acids, and alcohol |
Reduction | By catalytic hydrogenation, using NaBH4, sulfurous acid, etc. |
Grignard reaction | |
Chlorination | NaOCl, SOCl2, PCl3, POCl3, etc. |
Enantiomer synthesis | Asymmetric reduction, Optical resolution |
Enzymatic reaction | Asymmetric hydrolysis, hydrolysis |
Kolbe-Schmitt reaction | Carbon dioxide |
Oxidation | Using H2O2, NaOCl, etc. |
Diazotization | NaNO2 |
Cyanation | -CONH2 → -CN |
Suzuki-Miyaura coupling | R-B(OH)2, Pd/C |
Sulfonation | Sulfuric acid, fuming sulfuric acid, sulfur trioxide-pyridine complex |
Nitration | Nitric acid, mixed acid, etc. |
Nitrosation | NaNO2 |
Glycosidation | BF3, methanesulfonic acid |
Photo-oxidation | Sodium lamp |
Friedel–Crafts reaction | Acylation, Alkylating |
Bromination | Br2 |
Formylation | HCHO, Vilsmeier reaction, etc. |
Mitsunobu reaction | |
Phosphorylation | POCl3, PCl3 |
Other organic synthesis reactions |
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Example of catalytic reduction |
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Photo-Oxidation | Bromination | |
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We have bromine tank system, so we can use bromine itself.
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Friedel-Crafts Reaction | Kolbe-Schmitt Reaction | |
We use Aluminum Chloride. We have know-how on removing by-produced Aluminum Hydrochloride. ![]() |
Reaction can be made under mild condition.
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|
Suzuki-Miyaura Coupling | ||
We can manufacture in actual equipment based on know-how regarding the use of Pd catalyst.
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