{"id":2312,"date":"2018-12-15T10:59:42","date_gmt":"2018-12-15T01:59:42","guid":{"rendered":"http:\/\/spera.rdy.jp\/?page_id=2312"},"modified":"2021-03-17T12:53:34","modified_gmt":"2021-03-17T03:53:34","slug":"contract","status":"publish","type":"page","link":"https:\/\/www.spera-nexus.co.jp\/en\/services\/manufacturing-function\/contract\/","title":{"rendered":"Contract Manufacturing"},"content":{"rendered":"<p>\nBased on our synthesis technology accumulated over a long period, we respond to requests for any type of outsourcing smoothly, from development stage to production.<\/p>\n<p>Thanks to completion of a new plant for small-scale GMP production, we have the production capacity to respond flexibly to various kinds of needs, from small-scale to large lot\u3000production, along with existing large automated facilities for GMP, and high-performance multi-purpose facilities.<br \/>\nUnder high quality control system that conforms to c-GMP and ICH standards and based on DMF, CEP registration, and experience with FDA inspections, we provide outsourcing services that will satisfy our customers.<br \/>\nIn addition, we proactively engage in EHS (Environment, Health, Safety) investment.\n<\/p>\n<div id=\"contract\">\n<div class=\"su-spoiler su-spoiler-style-default su-spoiler-icon-chevron su-spoiler-custom su-spoiler-closed\" data-scroll-offset=\"0\" data-anchor-in-url=\"no\"><div class=\"su-spoiler-title\" tabindex=\"0\" role=\"button\"><span class=\"su-spoiler-icon\"><\/span>Contract Manufacturing Flow<\/div><div class=\"su-spoiler-content su-u-clearfix su-u-trim\">\n<img decoding=\"async\" class=\"alignnone size-full lazyload\" data-src=\"\/wp-content\/uploads\/2021\/02\/flow.png\" alt=\"Contract Manufacturing Flow\" src=\"data:image\/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==\" style=\"--smush-placeholder-width: 896px; --smush-placeholder-aspect-ratio: 896\/421;\" \/><noscript><img decoding=\"async\" class=\"alignnone size-full\" src=\"\/wp-content\/uploads\/2021\/02\/flow.png\" alt=\"Contract Manufacturing Flow\" \/><\/noscript><\/div><\/div>\n<div class=\"su-spoiler su-spoiler-style-default su-spoiler-icon-chevron su-spoiler-custom su-spoiler-closed\" data-scroll-offset=\"0\" data-anchor-in-url=\"no\"><div class=\"su-spoiler-title\" tabindex=\"0\" role=\"button\"><span class=\"su-spoiler-icon\"><\/span>Main Facilities<\/div><div class=\"su-spoiler-content su-u-clearfix su-u-trim\">\n<div class=\"table_title\">Pilot Plant<\/div>\n<div class=\"table_body pilot\">\n<table>\n<tbody>\n<tr>\n<th class=\"col1\">Facilities<\/th>\n<th class=\"col2\">Specification<\/th>\n<th class=\"col3\">Capacity<\/th>\n<th class=\"col4\">Quantity<\/th>\n<\/tr>\n<tr>\n<td rowspan=\"5\">Reactors<br \/>Normal Pressure, -5~140\u2103(200\u2103)<\/td>\n<td>Glass Lining<\/td>\n<td>10L<\/td>\n<td>5<\/td>\n<\/tr>\n<tr>\n<td rowspan=\"2\">Glass Lining<\/td>\n<td>300L<\/td>\n<td>5<\/td>\n<\/tr>\n<tr>\n<td>1,000L<\/td>\n<td>1<\/td>\n<\/tr>\n<tr>\n<td rowspan=\"2\">Stainless<\/td>\n<td>300L<\/td>\n<td>3<\/td>\n<\/tr>\n<tr>\n<td>500L<\/td>\n<td>1<\/td>\n<\/tr>\n<tr>\n<td>Autoclave<br \/>~10kg\/cm<sup>2<\/sup>, -5~140\u2103<\/td>\n<td>Stainless<\/td>\n<td>200L<\/td>\n<td>1<\/td>\n<\/tr>\n<tr>\n<td>Vacuum Distilling Apparatus<br \/>3mmHg, \uff5e200\u2103<\/td>\n<td>Stainless<\/td>\n<td>200L<\/td>\n<td>1<\/td>\n<\/tr>\n<tr>\n<td rowspan=\"3\">Centrifuge<\/td>\n<td rowspan=\"3\">Top emission type, Stainless<\/td>\n<td>\u03c612 inches<\/td>\n<td>1<\/td>\n<\/tr>\n<tr>\n<td>\u03c620 inches<\/td>\n<td>2<\/td>\n<\/tr>\n<tr>\n<td>\u03c630 inches<\/td>\n<td>1<\/td>\n<\/tr>\n<tr>\n<td rowspan=\"2\">Filter Separators<\/td>\n<td>Pressurization, Stainless<\/td>\n<td><\/td>\n<td>2<\/td>\n<\/tr>\n<tr>\n<td>Reduced pressure, Stainless<\/td>\n<td><\/td>\n<td>2<\/td>\n<\/tr>\n<tr>\n<td rowspan=\"3\">Dryers<\/td>\n<td>Shelf- fan dryer, Stainless-steel<\/td>\n<td><\/td>\n<td>1<\/td>\n<\/tr>\n<tr>\n<td>Shelf-type vacuum dryer, Stainless<\/td>\n<td><\/td>\n<td>1<\/td>\n<\/tr>\n<tr>\n<td>Conical type vacuum dryer, Stainless<\/td>\n<td>30L<\/td>\n<td>1<\/td>\n<\/tr>\n<tr>\n<td>Clean Room<\/td>\n<td>Clean level: 100,000\/ft<sup>3<\/sup><br \/>Ventilation: 20 times\/hr or more<\/td>\n<td><\/td>\n<td>1<\/td>\n<\/tr>\n<tr>\n<td>Freezer<br \/>Medium -20\u2103<\/td>\n<td>3600kcal\/hr<\/td>\n<td><\/td>\n<td>1<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<div class=\"table_title\">Commercial Plant<\/div>\n<div class=\"table_body real\">\n<table>\n<tbody>\n<tr>\n<th class=\"col1\">Facilities<\/th>\n<th class=\"col2\">Specification<\/th>\n<th class=\"col3\">Capacity<\/th>\n<th class=\"col4\">Quantity<\/th>\n<\/tr>\n<tr>\n<td rowspan=\"3\">Reactors<br \/>Normal Pressure\uff5e100mmHg, \uff0d5\uff5e140\u2103\uff08200\u2103\uff09<\/td>\n<td>Glass Lining<\/td>\n<td>2m<sup>3<\/sup>\uff5e10m<sup>3<\/sup><\/td>\n<td>41<\/td>\n<\/tr>\n<tr>\n<td>Stainless<\/td>\n<td>1m<sup>3<\/sup>\uff5e10m<sup>3<\/sup><\/td>\n<td>67<\/td>\n<\/tr>\n<tr>\n<td>Ti clad<\/td>\n<td>2.5m<sup>3<\/sup><\/td>\n<td>2<\/td>\n<\/tr>\n<tr>\n<td rowspan=\"2\">Autoclaves<br \/>\uff5e10kg\/cm<sup>2<\/sup>, \uff0d5\uff5e140\u2103<\/td>\n<td>Stainless<\/td>\n<td>2m<sup>3<\/sup>\uff5e4m<sup>3<\/sup><\/td>\n<td>5<\/td>\n<\/tr>\n<tr>\n<td>Glass Lining<\/td>\n<td>4m<sup>3<\/sup><\/td>\n<td>1<\/td>\n<\/tr>\n<tr>\n<td>Photo-reactor<br \/>600\u301c700nm<\/td>\n<td>Stainless<br \/>Sodium Lamp<\/td>\n<td><\/td>\n<td>1<\/td>\n<\/tr>\n<tr>\n<td>Vacuum Distilling Apparatus<br \/>3mmHg, \uff5e180\u2103, N=12<\/td>\n<td>Stainless<\/td>\n<td>1m<sup>3<\/sup>\uff5e7m<sup>3<\/sup><\/td>\n<td>3<\/td>\n<\/tr>\n<tr>\n<td rowspan=\"2\">Centrifuges<\/td>\n<td>Bottom emission type, Stainless<\/td>\n<td>\u03c624\uff5e55 inches<\/td>\n<td>5<\/td>\n<\/tr>\n<tr>\n<td>Top emission type, Stainless<\/td>\n<td>\u03c624\uff5e55 inches<\/td>\n<td>21<\/td>\n<\/tr>\n<tr>\n<td rowspan=\"3\">Filter separators<\/td>\n<td>Pressurization, Stainless<\/td>\n<td><\/td>\n<td>18<\/td>\n<\/tr>\n<tr>\n<td>Reduced pressure, Stainless<\/td>\n<td><\/td>\n<td>29<\/td>\n<\/tr>\n<tr>\n<td>Reduced pressure, FRP<\/td>\n<td><\/td>\n<td>1<\/td>\n<\/tr>\n<tr>\n<td rowspan=\"5\">Dryers<\/td>\n<td>Shelf-type fan dryer, Stainless<\/td>\n<td><\/td>\n<td>22<\/td>\n<\/tr>\n<tr>\n<td>Conical type vacuum dryer, Stainless<\/td>\n<td>2\uff5e2.5m<sup>3<\/sup><\/td>\n<td>6<\/td>\n<\/tr>\n<tr>\n<td>Clinical type vacuum dryer, Glass Lining<\/td>\n<td>2m<sup>3<\/sup><\/td>\n<td>2<\/td>\n<\/tr>\n<tr>\n<td rowspan=\"2\">Nauta-type vacuum dryer, Stainless<\/td>\n<td>1m<sup>3<\/sup><\/td>\n<td>3<\/td>\n<\/tr>\n<tr>\n<td>2m<sup>3<\/sup><\/td>\n<td>5<\/td>\n<\/tr>\n<tr>\n<td rowspan=\"5\">Mills<\/td>\n<td>Pin mill, Stainless<\/td>\n<td><\/td>\n<td>9<\/td>\n<\/tr>\n<tr>\n<td>Hammer mill, Stainless<\/td>\n<td><\/td>\n<td>3<\/td>\n<\/tr>\n<tr>\n<td>Power mill, Stainless<\/td>\n<td><\/td>\n<td>1<\/td>\n<\/tr>\n<tr>\n<td>Feather mill, Stainless<\/td>\n<td><\/td>\n<td>1<\/td>\n<\/tr>\n<tr>\n<td>Jet mill, Stainless<\/td>\n<td><\/td>\n<td>1<\/td>\n<\/tr>\n<tr>\n<td rowspan=\"3\">Clean Rooms<\/td>\n<td rowspan=\"3\">Clean level: 100,000\/ft<sup>3<\/sup><br \/>Ventilation: More than 20 times\/hr<\/td>\n<td>Centrifuge rooms<\/td>\n<td>10<\/td>\n<\/tr>\n<tr>\n<td>Drying rooms<\/td>\n<td>11<\/td>\n<\/tr>\n<tr>\n<td>Milling rooms<\/td>\n<td>12<\/td>\n<\/tr>\n<tr>\n<td>Ice Maker<\/td>\n<td>Stainless 2.4t\/day<\/td>\n<td><\/td>\n<td>1<\/td>\n<\/tr>\n<tr>\n<td>Wastewater treatment<\/td>\n<td>Activated sludge<\/td>\n<td><\/td>\n<td><\/td>\n<\/tr>\n<tr>\n<td>Freezers<\/td>\n<td>Medium -20\u2103<br \/>Inside -10 ~ -5\u2103<\/td>\n<td>46kW<\/td>\n<td>16<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<\/div><\/div>\n<div class=\"su-spoiler su-spoiler-style-default su-spoiler-icon-chevron su-spoiler-custom su-spoiler-closed\" data-scroll-offset=\"0\" data-anchor-in-url=\"no\"><div class=\"su-spoiler-title\" tabindex=\"0\" role=\"button\"><span class=\"su-spoiler-icon\"><\/span>Main Analytical Equipment (Shizuoka Factory)<\/div><div class=\"su-spoiler-content su-u-clearfix su-u-trim\">\n<div class=\"table_explain\">\nWe have necessary analytical equipment for product quality control.<br \/>\nWe operate accordance with data integrity.<br \/>\nWe can use <a href=\"\/en\/services\/manufacturing-function\/research\/\">the equipment of R&#038;D in Tokyo<\/a> depending on the customer\u2019s requirements.\n<\/div>\n<div class=\"table_body analysis\">\n<table>\n<tbody>\n<tr>\n<th class=\"col1\">Equipment<\/th>\n<th class=\"col2\">Specification<\/th>\n<\/tr>\n<tr>\n<td>HPLC<\/td>\n<td>High and low pressure gradients<br \/>Detector: UV, UV-VIS, RI<\/td>\n<\/tr>\n<tr>\n<td>GC<\/td>\n<td>Detector: FID<br \/>Equipped with a head-space sample injection device<\/td>\n<\/tr>\n<tr>\n<td>ICP-MS<\/td>\n<td>Responding to elements subject to ICH-Q3D Step 4<br \/>Responding to organic solvents<\/td>\n<\/tr>\n<tr>\n<td>FT-IR<\/td>\n<td>7800\uff5e350cm<sup>-1<\/sup><\/td>\n<\/tr>\n<tr>\n<td>UV-visible spectrophotometers<\/td>\n<td>190\uff5e900nm<\/td>\n<\/tr>\n<tr>\n<td>Karl Fischer moisture meter<\/td>\n<td>Volumetric procedure<br \/>Coulometric titration<\/td>\n<\/tr>\n<tr>\n<td>Potentiometric titrator<\/td>\n<td>pH 0.00\uff5e14.00<\/td>\n<\/tr>\n<tr>\n<td>Polarimeter<\/td>\n<td>589nm (Na)<\/td>\n<\/tr>\n<tr>\n<td>Particle size distribution analyzer<\/td>\n<td>Laser diffraction type(dry and wet), microscope type, air permeability method<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<\/div><\/div>\n<div class=\"su-spoiler su-spoiler-style-default su-spoiler-icon-chevron su-spoiler-custom su-spoiler-closed\" data-scroll-offset=\"0\" data-anchor-in-url=\"no\"><div class=\"su-spoiler-title\" tabindex=\"0\" role=\"button\"><span class=\"su-spoiler-icon\"><\/span>Main Reactions<\/div><div class=\"su-spoiler-content su-u-clearfix su-u-trim\">\n<div class=\"table_explain\">\nTechnologies in <span class=\"emphasis\">orange highlighted<\/span> are our specialty technologies.\n<\/div>\n<div class=\"table_body reaction\">\n<table>\n<tbody>\n<tr>\n<th>Acylation<\/th>\n<td>Acid chloride, acid anhydride, etc.<\/td>\n<\/tr>\n<tr>\n<th>Amidation<\/th>\n<td>Ammonia, amines, etc.<\/td>\n<\/tr>\n<tr>\n<th>Amination<\/th>\n<td>By reduction of nitro and nitroso, and by using amines<\/td>\n<\/tr>\n<tr>\n<th>Alkylation<\/th>\n<td>Dialkyl sulfuric acid, alkyl halide, etc.<\/td>\n<\/tr>\n<tr>\n<th>Esterification<\/th>\n<td>Various organic and inorganic acids, and alcohol<\/td>\n<\/tr>\n<tr>\n<th class=\"emphasis\">Reduction<\/th>\n<td><span class=\"emphasis\">By catalytic hydrogenation<\/span>, using NaBH4, sulfurous acid, etc.<\/td>\n<\/tr>\n<tr>\n<th>Grignard reaction<\/th>\n<td><\/td>\n<\/tr>\n<tr>\n<th>Chlorination<\/th>\n<td>NaOCl, SOCl<sub>2<\/sub>, PCl<sub>3<\/sub>, POCl<sub>3<\/sub>, etc.<\/td>\n<\/tr>\n<tr>\n<th class=\"emphasis\">Enantiomer synthesis<\/th>\n<td>Asymmetric reduction, <span class=\"emphasis\">Optical resolution<\/span><\/td>\n<\/tr>\n<tr>\n<th>Enzymatic reaction<\/th>\n<td>Asymmetric hydrolysis, hydrolysis<\/td>\n<\/tr>\n<tr>\n<th class=\"emphasis\">Kolbe-Schmitt reaction<\/th>\n<td class=\"emphasis\">Carbon dioxide<\/td>\n<\/tr>\n<tr>\n<th class=\"emphasis\">Oxidation<\/th>\n<td>Using H<sub>2<\/sub>O<sub>2<\/sub>, NaOCl, etc.<\/td>\n<\/tr>\n<tr>\n<th>Diazotization<\/th>\n<td>NaNO<sub>2<\/sub><\/td>\n<\/tr>\n<tr>\n<th>Cyanation<\/th>\n<td>\uff0dCONH<sub>2<\/sub> \u2192 \uff0dCN<\/td>\n<\/tr>\n<tr>\n<th class=\"emphasis\">Suzuki-Miyaura coupling<\/th>\n<td class=\"emphasis\">R-B(OH)<sub>2<\/sub>, Pd\/C<\/td>\n<\/tr>\n<tr>\n<th>Sulfonation<\/th>\n<td>Sulfuric acid, fuming sulfuric acid, sulfur trioxide-pyridine complex<\/td>\n<\/tr>\n<tr>\n<th>Nitration<\/th>\n<td>Nitric acid, mixed acid, etc.<\/td>\n<\/tr>\n<tr>\n<th>Nitrosation<\/th>\n<td>NaNO<sub>2<\/sub><\/td>\n<\/tr>\n<tr>\n<th class=\"emphasis\">Glycosidation<\/th>\n<td class=\"emphasis\">BF<sub>3<\/sub>, methanesulfonic acid<\/td>\n<\/tr>\n<tr>\n<th class=\"emphasis\">Photo-oxidation<\/th>\n<td class=\"emphasis\">Sodium lamp<\/td>\n<\/tr>\n<tr>\n<th class=\"emphasis\">Friedel\u2013Crafts reaction<\/th>\n<td class=\"emphasis\">Acylation, Alkylating<\/td>\n<\/tr>\n<tr>\n<th class=\"emphasis\">Bromination<\/th>\n<td class=\"emphasis\">Br<sub>2<\/sub><\/td>\n<\/tr>\n<tr>\n<th>Formylation<\/th>\n<td>HCHO, Vilsmeier reaction, etc.<\/td>\n<\/tr>\n<tr>\n<th>Mitsunobu reaction<\/th>\n<td><\/td>\n<\/tr>\n<tr>\n<th class=\"emphasis\">Phosphorylation<\/th>\n<td class=\"emphasis\">POCl<sub>3<\/sub>, PCl<sub>3<\/sub><\/td>\n<\/tr>\n<tr>\n<th>Other organic synthesis reactions<\/th>\n<td><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<\/div><\/div>\n<div class=\"su-spoiler su-spoiler-style-default su-spoiler-icon-chevron su-spoiler-custom su-spoiler-closed\" data-scroll-offset=\"0\" data-anchor-in-url=\"no\"><div class=\"su-spoiler-title\" tabindex=\"0\" role=\"button\"><span class=\"su-spoiler-icon\"><\/span>Our technology<\/div><div class=\"su-spoiler-content su-u-clearfix su-u-trim\">\n<div class=\"table_title\">Catalytic reduction<\/div>\n<div class=\"table_explain\">\nWe have well knowledge and many experiences of actual production relating to catalytic reduction.<br \/>\nWe will select and provide the best reduction condition based on customer\u2019s reaction.<br \/>\nIn addition, we have established safe and reliable handling operations from charging to recovery.<br \/>\nWe have also realized cost reduction through recycling in collaboration with catalyst manufacturers.\n<\/div>\n<div class=\"table_body technology1\">\n<table>\n<tbody>\n<tr>\n<td><img decoding=\"async\" class=\"alignnone size-full lazyload\" data-src=\"\/wp-content\/uploads\/2021\/02\/29fd6fc154dab0d83471b2b00160e39c.png\" alt=\"Catalytic reduction\" src=\"data:image\/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==\" style=\"--smush-placeholder-width: 631px; --smush-placeholder-aspect-ratio: 631\/373;\" \/><noscript><img decoding=\"async\" class=\"alignnone size-full\" src=\"\/wp-content\/uploads\/2021\/02\/29fd6fc154dab0d83471b2b00160e39c.png\" alt=\"Catalytic reduction\" \/><\/noscript><\/td>\n<\/tr>\n<tr>\n<th>Example of catalytic reduction<\/th>\n<\/tr>\n<tr>\n<td><img decoding=\"async\" class=\"alignnone size-full lazyload\" data-src=\"\/wp-content\/uploads\/2021\/02\/f782396fe59eec2701828f70e9636c9f.png\" alt=\"Example of catalytic reduction\" src=\"data:image\/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==\" style=\"--smush-placeholder-width: 864px; --smush-placeholder-aspect-ratio: 864\/497;\" \/><noscript><img decoding=\"async\" class=\"alignnone size-full\" src=\"\/wp-content\/uploads\/2021\/02\/f782396fe59eec2701828f70e9636c9f.png\" alt=\"Example of catalytic reduction\" \/><\/noscript><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<div class=\"table_body technology2\">\n<table>\n<tbody>\n<tr>\n<th>Photo-Oxidation<\/th>\n<td class=\"table_space\"><\/td>\n<th>Bromination<\/th>\n<\/tr>\n<tr>\n<td><img decoding=\"async\" class=\"alignnone size-full lazyload\" data-src=\"\/wp-content\/uploads\/2021\/01\/2695c184269a662040365c8cb7a4dbc2.png\" alt=\"Photo-Oxidation\" src=\"data:image\/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==\" style=\"--smush-placeholder-width: 545px; --smush-placeholder-aspect-ratio: 545\/121;\" \/><noscript><img decoding=\"async\" class=\"alignnone size-full\" src=\"\/wp-content\/uploads\/2021\/01\/2695c184269a662040365c8cb7a4dbc2.png\" alt=\"Photo-Oxidation\" \/><\/noscript><\/td>\n<td class=\"table_space\"><\/td>\n<td>We have bromine tank system, so we can use bromine itself.<br \/>\n<img decoding=\"async\" class=\"alignnone size-full lazyload\" data-src=\"\/wp-content\/uploads\/2021\/01\/69c412dfc7314166afff4feeb3873a4c.png\" alt=\"Bromination\" src=\"data:image\/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==\" style=\"--smush-placeholder-width: 460px; --smush-placeholder-aspect-ratio: 460\/139;\" \/><noscript><img decoding=\"async\" class=\"alignnone size-full\" src=\"\/wp-content\/uploads\/2021\/01\/69c412dfc7314166afff4feeb3873a4c.png\" alt=\"Bromination\" \/><\/noscript><\/td>\n<\/tr>\n<tr>\n<th>Friedel-Crafts Reaction<\/th>\n<td class=\"table_space\"><\/td>\n<th>Kolbe-Schmitt Reaction<\/th>\n<\/tr>\n<tr>\n<td rowspan=\"3\">We use Aluminum Chloride.<br \/>We have know-how on removing by-produced Aluminum Hydrochloride.<br \/>\n<img decoding=\"async\" class=\"alignnone size-full lazyload\" data-src=\"\/wp-content\/uploads\/2021\/01\/f2a964d8925a4d7562c6f59890e60085.png\" alt=\"Friedel-Crafts Reaction\" src=\"data:image\/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==\" style=\"--smush-placeholder-width: 529px; --smush-placeholder-aspect-ratio: 529\/353;\" \/><noscript><img decoding=\"async\" class=\"alignnone size-full\" src=\"\/wp-content\/uploads\/2021\/01\/f2a964d8925a4d7562c6f59890e60085.png\" alt=\"Friedel-Crafts Reaction\" \/><\/noscript><\/td>\n<td rowspan=\"3\" class=\"table_space\"><\/td>\n<td>Reaction can be made under mild condition.<br \/>\n<img decoding=\"async\" class=\"alignnone size-full lazyload\" data-src=\"\/wp-content\/uploads\/2021\/01\/142a80eaead8492967a2b202842a5750.png\" alt=\"Kolbe-Schmitt Reaction\" src=\"data:image\/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==\" style=\"--smush-placeholder-width: 402px; --smush-placeholder-aspect-ratio: 402\/121;\" \/><noscript><img decoding=\"async\" class=\"alignnone size-full\" src=\"\/wp-content\/uploads\/2021\/01\/142a80eaead8492967a2b202842a5750.png\" alt=\"Kolbe-Schmitt Reaction\" \/><\/noscript><\/td>\n<\/tr>\n<tr>\n<th>Suzuki-Miyaura Coupling<\/th>\n<\/tr>\n<tr>\n<td>We can manufacture in actual equipment based on know-how regarding the use of Pd catalyst.<br \/>\n<img decoding=\"async\" class=\"alignnone size-full lazyload\" data-src=\"\/wp-content\/uploads\/2021\/01\/88eca537dc916f45188e8c3430481a74.png\" alt=\"Suzuki-Miyaura Coupling\" src=\"data:image\/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==\" style=\"--smush-placeholder-width: 584px; --smush-placeholder-aspect-ratio: 584\/136;\" \/><noscript><img decoding=\"async\" class=\"alignnone size-full\" src=\"\/wp-content\/uploads\/2021\/01\/88eca537dc916f45188e8c3430481a74.png\" alt=\"Suzuki-Miyaura Coupling\" \/><\/noscript><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<\/div><\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Based on our synthesis technology accumulated over a long period, we respond to requests for any type of outso [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":7368,"menu_order":1,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_locale":"en_US","_original_post":"55","footnotes":""},"acf":[],"_links":{"self":[{"href":"https:\/\/www.spera-nexus.co.jp\/wp-json\/wp\/v2\/pages\/2312"}],"collection":[{"href":"https:\/\/www.spera-nexus.co.jp\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.spera-nexus.co.jp\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.spera-nexus.co.jp\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.spera-nexus.co.jp\/wp-json\/wp\/v2\/comments?post=2312"}],"version-history":[{"count":19,"href":"https:\/\/www.spera-nexus.co.jp\/wp-json\/wp\/v2\/pages\/2312\/revisions"}],"predecessor-version":[{"id":10825,"href":"https:\/\/www.spera-nexus.co.jp\/wp-json\/wp\/v2\/pages\/2312\/revisions\/10825"}],"up":[{"embeddable":true,"href":"https:\/\/www.spera-nexus.co.jp\/wp-json\/wp\/v2\/pages\/7368"}],"wp:attachment":[{"href":"https:\/\/www.spera-nexus.co.jp\/wp-json\/wp\/v2\/media?parent=2312"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}